Scientist I position at Beckman Coulter Life Sciences – APPLY NOW
Beckman Coulter Life Sciences is seeking a dedicated and experienced Scientist I to join their Technical Operations team at their Bangalore facility. As a Scientist I, you will play a pivotal role in supporting the product transfer process from different regions worldwide and contribute to the establishment of new processes or process validations.
Role : Scientist I
Company : Beckman Coulter Life Sciences
Location : Bangalore, Karnataka, India
Category : Engineering
Job Id : R1246932
Education : Advanced degree in Chemistry
Summary of responsibilities of Scientist I position at Beckman :
- Technical operations scientist I support the technical operations reagent team in product transfer from different parts of the globe and setting up the new process or validating the processes.
- Contributes to the support of development, implementation and maintenance of manufacturing methods, techniques, processes, and product.
- Interfacing as appropriate with Development, Quality, Manufacturing, Purchasing and suppliers.
- The incumbent assists with coordinating the release of new and enhancements to existing products; participates in design reviews, inspections, and product quality processes; aids the development product structures and ensures manufacturing documents are created, updated and in compliance with company standards, ISO and GMP as required.
- Boundary Conditions/Authority Levels: Receives instruction on routine work, instructions on new assignments.
- Essential Duties and Responsibilities: include the following. Other duties may be assigned.
- Well versed with Manufacturing/QC/R&D related activities.
- Follows standard practices and procedures in analyzing situations or data from which answers can be readily obtained.
- Ensures strict adherence to good laboratory and good documentation practices throughout the design and development cycle.
- Applies analytical skills and independent judgment to develop innovative, practical, and consistent solutions to a wide range of complex problems.
- Involve in study planning to align with requirements standards and regulatory requirements and ensures the studies are conducted in agreement with approved plans.
- Flexible to take up new challenges & performs other related duties as required.
- Coordinate with external technical team for product transfer (both external transfer and internal transfer)
- Execute smooth Technology Transfer of products from Design and development to Manufacturing.
- Should perform experiments to control or to manufacture reagents according to procedures, technical protocols in respect of QA and RA regulation and GMP rules.
- Analyze results, solve simple technical issue/problem, and inform in an appropriate ways issues identified.
- Organize tasks by taking into an account priority defined by Team Leader.
- Responsible for follow all company guidelines related to Health, Safety and
- Environmental practices and that all resources needed to do so are available and in good condition.
- Responsible for ensuring personal and company compliance with all Federal, State, local and company regulations, policies and procedures for Health, Safety and Environmental compliance.
- Contribute to the redaction and the update of experimental reports, procedures, or manufacturing/ QC instructions. should be trained on Protocol writing for SOP and manufacturing procedures.
- Support the Technical operations by carrying out Organic synthesis of fluorescent dyes suitable for Flow Cytometry applications.
- Perform purification of the organic compounds using different types of column chromatography techniques.
- Evaluate photo physical properties of dyes using Spectrophotometry.
- Having polymer chemistry and Conjugation chemistry knowledge brings additional advantage to this role.
Experience required for Scientist I position at Beckman :
- Advanced degree in Chemistry, for example bachelor’s or master’s degree with 4-7 years’ experience in field.
- Hands on experience on protein purification techniques, Basic knowledge on Flow cytometry or other assay development techniques.
- Hands on Experience with various modes of Preparative or Analytical chromatography (Affinity, IEC, MMC, SEC) and advanced laboratory measurement systems are desired (AKTA, HPLC, Spectrophotometer, Protein estimation techniques, FRET analysis).
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About the company : Beckman Coulter Life Sciences’ mission is to empower those seeking answers to life’s most important scientific and healthcare questions. With a legacy spanning 80+ years, they have long been a trusted partner to our customers, who are working to transform science and healthcare with the next groundbreaking discovery. As part of their team of more than 2,900 associates across 130 countries, you’ll help drive the company’s vision of accelerating answers—and our commitment to excellence.
Below are some interview questions and possible answers for the Scientist I position at Beckman Coulter Life Sciences:
Interview Question 1: Can you describe your experience in product transfer and setting up new processes in the field of technical operations?
Answer: Certainly! In my previous roles, I have been actively involved in product transfer projects, collaborating with teams across different regions globally. I have successfully facilitated the seamless transfer of products from one location to another while ensuring compliance with company standards, ISO, and GMP regulations. Additionally, I have been instrumental in setting up new processes and validating them, contributing to the development, implementation, and maintenance of manufacturing methods and techniques. My experience in technical operations has honed my analytical skills and allowed me to develop innovative solutions to complex challenges.
Interview Question 2: How do you ensure strict adherence to good laboratory and documentation practices during the design and development cycle?
Answer: Adherence to good laboratory and documentation practices is paramount in ensuring the quality and reliability of our work. I consistently follow standard practices and procedures, meticulously recording data and results to maintain accurate and transparent documentation. Moreover, I actively promote a culture of compliance within the team, conducting regular training sessions and encouraging open communication about best practices. By emphasizing the importance of proper documentation from the onset of projects, I ensure that our processes are traceable, reproducible, and compliant with industry regulations.
Interview Question 3: Can you share an example of a complex problem you encountered in your previous role and the steps you took to develop a practical and innovative solution?
Answer: One of the complex problems I faced involved optimizing the purification process of a particular organic compound using column chromatography. The process was yielding inconsistent results, leading to challenges in meeting quality standards. To address this, I first conducted a thorough analysis of the data and experimental conditions to identify potential factors influencing the outcome. I then collaborated with a cross-functional team, including R&D and Quality, to brainstorm and implement process improvements. By introducing modifications in the chromatography technique and optimizing the solvent system, we achieved a more stable and reproducible purification process, resulting in improved product quality.
Interview Question 4: How do you ensure successful Technology Transfer of products from Design and Development to Manufacturing?
Answer: Successful Technology Transfer requires meticulous planning and coordination. I ensure effective communication between the Development team and Manufacturing, providing all necessary documentation and technical support. I conduct comprehensive feasibility studies and risk assessments to anticipate potential challenges during the transfer process. Additionally, I work closely with external technical teams, when required, to facilitate smooth product transfers. By adhering to approved plans and regulatory requirements, I ensure a seamless transition and minimize disruptions to production timelines.
Interview Question 5: In your experience with Organic synthesis of fluorescent dyes, how do you evaluate the photo physical properties of dyes using Spectrophotometry?
Answer: When evaluating photo physical properties of dyes using Spectrophotometry, I first prepare samples of the synthesized dyes and establish appropriate experimental conditions. I then use a spectrophotometer to measure the absorption and emission spectra of the dyes, capturing their unique photo physical characteristics. By analyzing the obtained data, I can determine key properties such as excitation and emission wavelengths, quantum yields, and extinction coefficients. These parameters play a crucial role in assessing the suitability of the dyes for Flow Cytometry applications and aid in designing effective experiments.
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