Triple-negative breast cancer

Triple-negative breast cancer –  Existing drug potential against the disease  

Scientists at the ICR have found that an already authorized breast cancer medicine could treat triple-negative breast cancer.

The research was supported by the research and care charity Breast Cancer Now. The study proposes that palbociclib (Ibrance) – could be utilized to treat around a 5th of people with triple-negative breast cancer (TNBC).

The study uncovered a method to identify triple-negative breast cancer tumours that could most likely respond to CDK4/6 inhibitors like palbociclib.

The researchers evaluated 200 of the most frequently modified genes in breast cancer to review how these genes’ modifications influence cancer’s ability to expand.

The ICR scientists discovered that TNBC cells with modifications that caused a decrease in the CREBBP protein levels could multiply much more intrusively and at a quicker speed.

Using 2 large patient data sources to additionally explore the role of reduced CREBBP tumor levels, the group additionally observed that this is connected to lower survival for triple-negative breast cancer patients.

Additionally, reduced levels of CREBBP occur in other cancers like uterine, ovarian, and some lung and bladder cancers – implying the importance it plays in tumor development or growth.

The scientists discovered

that when the protein levels are reduced, tumor cells change how they divide rather than depending upon the proteins CDK4 and CDK6 – these can be hindered by CDK4/6 inhibitors.

Presently, secondary or metastatic breast cancers are treated using palbociclib in the United Kingdom. The researchers evaluated the performance of this medicine in cancer cells with CREBBP modifications in the laboratory and animal models.

They discovered that the medicine worked, even when tested on regular chemotherapy-resistant TNBCs that did not have CREBBP.

Rachael Natrajan, Team Leader in Functional Genomics, ICR, stated that their research reveals what stimulates the growth of some TNBCs and infers the promising opportunity that a previously-authorized breast cancer drug could be utilized to aid patients with this sort of disease.

She further stated that their research outcomes were feasible as they used a cutting-edge model, including the growth of 3D ‘mini tumours’ in the laboratory, to more carefully reflect how tumours develop in the body.

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