Jubilant Biosys Pharmaceutical Chemistry & Pharma Research Job Opening – Apply Now
Organization: Jubilant Biosys
Designation & Level: Research Associate/Sr. Research Associate (A3/A4)
Location: Greater Noida
Department: DMPK
Key Responsibilities
In Vitro ADME studies
- Read and understand various in vitro ADME protocols
- Conduct in vitro stability (liver microsomes, plasma, and in any other relevant matrix, chemical stability) experiments for new chemical entities
- Conduct the following in vitro ADME experiments:
logP, logD, pKa measurements - CYP induction and inhibition assays
- Permeability determinations (Caco-2, MDCK, etc.) in relevant cell lines
- CYP phenotyping in purified enzyme systems
- Solubility determinations (kinetic, thermodynamic, simulated fluids)
Bioanalysis:
- Read and understand the bioanalysis sections in the study protocols
- LC-MS/MS and HPLC-UV/PDA method development and validation (partial and complete)
- Develop fit-for-purpose LC-MS/MS methods for routine in vitro sample analysis
- Extract data from the instrument, conduct bioanalytical QC, and share reports with the stakeholders within the DMPK department
- Experience in handling bioanalytical method development for various matrices with a focus on in vitro samples; understanding of handling plasma, blood, various tissues, urine, and feces is a plus but not mandatory
- Development of LC-MS/MS methods for biochemical and cell-based screening of NCEs is a plus but not mandatory
- General LC-MS/MS and HPLC maintenance and troubleshooting
Data analysis and report generation:
- Understand the quality of bioanalytical data
- Conduct data analysis employing Phoenix WinNonLin software is a plus but not mandatory
- Ability to calculate in vitro results/parameters on Excel spreadsheets
- Report generation (Excel format, Word format, and PowerPoint presentation) and sharing with the line manager
- Generate reports in both GLP and non-GLP formats (based on the requirement)
Person Profile
Qualification:
- M.Sc / M.Tech (Biochemistry, Pharmaceutical Chemistry, Biotech background)
- Master in Pharmacy (M.Pharm)
Experience:
- 2-6 years of relevant experience
- Experience in a drug discovery industry/CRO in the DMPK department
