Syngene M Pharma Invitro Associate Scientist Vacancy – Apply Online
Syngene hiring, recruitment 2023, pharma job opening 2023, M Pharma job opening 2023, pharma job opening 2023, Candidates with masters degree in pharma may apply for the job opening at Syngene, Intrested and eligible candidates may check out all the details on the same below:
Dont forget to check out possible interview questions for this job below.
Job Title: Associate Scientist – Invitro ADME
Job Location: Hyderabad
Reporting to: Senior Lead Investigator
Job Grade: 8-I
Educational Qualification:
M Pharm. in any pharmaceutical science or M Sc. in biological science.
Experience:
Experience in CRO (DMPK/ADME) research with 3 to 6 years
Technical/functional Skills:
- Experience in Physicochemical assays and binding assays
- Demonstrated Capability in conducting Solubility, Log D, Log P, PAMPA etc.
- Comprehensive understanding of Physicochemical and technical expertise in trouble shooting the assay.
- In depth understanding of physicochemical studies is highly desirable related to the ADME
- In depth understanding of biochemical and aspects of binding studies is highly desirable related to the ADME
- Good, demonstrated knowledge in software such as Microsoft excel and Graph pad
- prismDemonstrated cross functional leadership capabilities
- Experience with automation is desirable
Behavioral Skills:
- Demonstrate ability to be a team player.
- Commitment to deliver the study reports within the agreed timelines
- Adaptability to changes in the dynamic lab environment
- Communicate confidently with colleagues and collaborators in the meetings and presentation of study reports and evidence of publications in the PEER reviewed Journals
Mandatory expectation for all roles as per Syngene safety guidelines
- Overall adherence to safe practices and procedures of oneself and the teams aligned.
- Contributing to development of procedures, practices and systems that ensures safe operations and compliance to company’s integrity & quality standards.
- Driving a corporate culture that promotes environment, health, and safety (EHS) mindset and operational discipline at the workplace at all times.
- Ensuring safety of self, teams and lab/plant by adhering to safety protocols and following environment, health, and safety (EHS) requirements at all times in the workplace.
- Ensure all assigned mandatory trainings related to data integrity, health, and safety measures are completed on time by all members of the team including self.
Compliance to Syngene’ s quality standards at all times.
Core Purpose of the Role:
- Support the ADME team by conducting the Physicochemical assays such as solubility, Log-D, Log P and binding studies with various matrices such as plasma, tissue homogenates with highest quality.
- Interact with cross functional scientific teams and external collaborators and remain as a subject matter expert in the field of ADME sciences
- Identification of new technologies to support highly demanding ADME sciences
- Time management and multi-tasking skills to meet the demand of high-volume wave 1 ADME assays to complete multiple projects within timelines.
- Contemporaneous recording of lab activities and experiments performed, practices high level of house keeping
- Adhere to all safety rules and maintains safe workplace.
- Predominantly laboratory-based job
- Extensive experience in planning in vitro ADME assays
- Design and execute In vitro ADME assays of different types, viz In vitro metabolic studies in microsomes, S9 and cytosol, Single point inhibition, reversible CYPIC50 inhibition and TDI-IC50 shift assays using Human liver microsomes.
- Experience in managing a team of 2 – 3 people.
Setting up KRA / KPI for the team members and monitoring their performance. - Seamless coordination with BA-DMPK group to design in-vitro ADME studies.
- Automation of In vitro ADME assays.
- Preparation of SOP’s and EOPs.
- Reporting of executed studies without any noncompliance.
- Reporting of study results clearly in the cross functional scientific meetings.
- Follow environment, health, and safety (EHS) requirements always in the workplace ensuring individual and lab/plant safety.
Key Responsibilities:
- Extensive experience in planning Physicochemical assays such as solubility, Log-D, Log P and binding assays
- Design and execute Physicochemical assays such as solubility, Log-D, Log P and PAMPA
- Design and execute binding assays in plasma, microsomes, brain and tissue homogenates assay
- Seamless coordination with BA-DMPK group execute binding studies.
Preparation of SOP’s and EOPs. - Reporting of executed studies without any noncompliance.
- Reporting of study results clearly in the cross functional scientific meetings.
- Understanding and demonstrating responsibility for safety of self & colleagues by following all safety protocols provided by Syngene
- Adherence to all environment, health, and safety (EHS) policies & standards at all times in the workplace
- Wearing all PPE as required.
- Adherence to all procedures related to Syngene’s data integrity policies
- Compliance to Syngene’s quality standards at all times.
Syngene Values: All employees will consistently demonstrate alignment with our core values
- Excellence
- Integrity
- Professionalism
Apply Online
Possible Interview Questions for the above job role:
- Can you tell us about your experience in conducting in vitro ADME assays and your technical expertise in the field?
Answer: Yes, I have 3 to 6 years of experience in CRO (DMPK/ADME) research, specifically in physicochemical assays and binding assays. I have conducted solubility, Log D, Log P, PAMPA, and binding assays in plasma, microsomes, brain, and tissue homogenates, and have a comprehensive understanding of physicochemical and biochemical aspects related to ADME.
2. How have you demonstrated your leadership capabilities in your previous roles, especially in managing a team of 2-3 people?
Answer: I have set up KRAs/KPIs for team members and monitored their performance. I have also provided guidance and support to team members to ensure that they meet their objectives. Additionally, I have coordinated with the BA-DMPK group to design in-vitro ADME studies and have ensured that study results are reported clearly in cross-functional scientific meetings.
3. Can you share an example of a time when you had to troubleshoot an assay and the steps you took to resolve the issue?
Answer: Yes, I faced an issue with a binding assay where the results were not consistent. I identified that the issue was due to the variation in the sample preparation technique. I discussed the issue with the team and implemented a new sample preparation technique to improve the assay’s consistency, which resulted in more reliable results.
4. How do you manage your time and prioritize tasks to ensure that you meet project timelines for high-volume wave 1 ADME assays?
Answer: I manage my time by planning and prioritizing my tasks based on their urgency and importance. I ensure that I maintain contemporaneous recording of lab activities and experiments performed and maintain a high level of housekeeping. Additionally, I have experience in setting up SOPs and EOPs, which helps me streamline my work processes and meet project timelines.
5. Can you give an example of a situation where you had to communicate confidently with colleagues and external collaborators during the presentation of study reports?
Answer: Yes, I recently presented the binding assay results to our cross-functional scientific team and external collaborators. I prepared an organized and clear presentation and used visual aids to help convey complex data. I also ensured that I was well-prepared to answer any questions that were asked, which resulted in a successful presentation and collaboration.
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