Syngene PhD Pharmaceutical Science Job Opening – Apply
Research Investigator/ Principal Investigator Job. Syngene invites postgraduate Pharmaceutical science candidates for the post of Research Investigator/ Principal Investigator. Interested and eligible candidates may apply online, Check out all the details on our website Rasayanika.com
Job Title: Research Investigator/ Principal Investigator
Job Location: Bangalore
Department: Discovery Biology
Educational Qualification:
A PhD in pharmaceutical sciences or biological science. Five or more years of Post-doctoral and/or Industrial experience in transporter protein sciences research.
Technical/Functional Skills:
- Comprehensive understanding of in vitro ADME assays and technical expertise in troubleshooting the assays
- Several years of experience in conducting In vitro cell-based assays using suspension and plateable hepatocytes and transporter (OATPs, OAT, OCT and MATES) transfected cell lines
- In-depth understanding of biochemical and aspects of enzyme kinetics is highly desirable related to the transporter proteins
- A reasonable understanding of PBPK aspects and DDI risk assessment related to transporter proteins are essential
- Demonstrated cross-functional leadership capabilities
- Experience with automation is desirable
Experience:
A PhD in pharmaceutical sciences . Five or more years of Post-doctoral and/or Industrial experience in transporter protein sciences research.
Behavioural Skills:
- Demonstrate the ability to be a team player.
- Commitment to deliver the study reports within the agreed timelines
- Adaptability to changes in the dynamic lab environment
- Communicate confidently with colleagues and collaborators in the meetings and
- presentation of study reports and evidence of publications in the PEER reviewed Journals
Job Purpose
- Scientific leadership role to establish Drug Transporter Protein Sciences Research Group
Interact with cross-functional scientific teams and external collaborators and remain as a subject matter expert in the field of transporter protein sciences - Identification of likely transporter interactions of lead compounds and provide mitigation strategy
- Build capability to understand physchem properties that are related to the transporter protein liabilities in drug discovery programs
- Preparation of IND packages to support investigative studies that are part of regulatory submissions
Key Responsibilities:
- Develop tools and reagents to investigate the role of drug transporters in the disposition of small molecules
- Integration of study results obtained from suspension and plateable hepatocytes to assess the contribution of uptake clearance mechanism in the overall disposition
- Seamless coordination within vivo DMPK group to design in vivo studies for integration of in vitro findings
- Design and execute In vitro uptake assays in suspension, plateable hepatocytes and in the transporter transfected cell lines
- Integration of mechanistic ADME study results with transporter protein functionally and provide directions for the progression of molecules
Preparation of SOP’s and EOPs - Reporting of the executed studies with a high level of data integrity
- Reporting of study results clearly in the cross-functional scientific meetings
- Follow environment, health, and safety (EHS) requirements at all times in the workplace ensuring individual and lab/plant safety
- Ensure environment, health, and safety (EHS) measures are imparted via training and adhered within the team
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