Lilly Computational Chemist Vacancy 2021 – Chemistry & Pharma
Research IDS uses information technology for the scientific discovery of new therapies that are safe and effective against diseases. Our work helps researchers follow the science from idea to data creates the basis for clinical designs to answer scientific questions. As a member of the Research IDS organization, you will work on efforts to streamline scientific experimentation, organize and manage data to drive analysis, and establish Advanced Analytics to enable the discovery of therapies and targets. You will have the opportunity to work in a highly technical, high pace, team-focused, and scientifically challenging area responsible for delivery or platforms to support an ever change research environment.
Job Title: Research IDS Computational Chemist
Location: India, Bengaluru
Eligibility Criteria: Masters Degree in Chemistry/M.Pharm/Ph.D. degree in computational chemistry /Organic chemistry/Pharmacy/ field with experience in computational techniques for drug discovery. Additional certification or knowledge in Linux, Unix, or programming would be advantageous
Job Scope/ Purpose: To involve, execute and be a leader in the area of molecular design and modeling supporting small molecule drug discovery.
Key Responsibilities
• Collaborate with colleagues in medicinal chemistry for providing scientific knowledge obtained through molecular modeling, supporting preclinical drug
discovery.• Deliver modeling results in computational chemistry
• Write and maintain records of observations and conclusions for every experiment in a timely manner. Communicate experimental results and provide routine updates
• Conducting literature searches for the target, structures related to the target, and any other relevant or key information.
• Writing scientific procedures, presentation of research summaries at project meetings.
• To work in an interdisciplinary team of integrated drug discovery.
• Develop computational hypothesis using molecular modeling tools for small molecule and or large (macromolecules, peptides, etc.
• Working closely with medicinal chemist/biologist to support designs of molecules (small and large) using computational models.
• Preparing and submitting reports in the relevant format, design sessions to the team.
Technical/Functional Skills:
• Good understanding of computational techniques relevant to drug discovery
• Familiarity with modeling tools such as Schrodinger (LiveDesign/Maestro/Bioluminate/Maerial Science) / MOE / Molecular dynamics tools / Quantum Mechanics / KNIME / Pipeline Pilot Tools/ Signals Lead Discovery
• Thorough with computational techniques relevant to small molecule or large (Peptide/protein engineering/antibody) molecule drug discovery
• Virtual screening, Structure-based design, Ligand-based drug/material design
• Molecular dynamics and Quantum chemistry is highly desirable
• Shape and electrostatic comparison, homology modeling, docking, pharmacophore modeling, Cheminformatics approaches
• Expert knowledge of open-source software for molecular dynamics simulations
• Working knowledge of python
• Experience implementing molecular simulations in a GPU hardware environment
• Must be detail-oriented, well organized with the ability to analyze and communicate data effectively
• Generate and maintain chemical libraries, perform statistical analysis of screening results and build SAR models
• Play a major role in lead identification, optimization, scaffold hopping, and fragment linking
Desirable Experience:
• 1-8 year/s experience in drug discovery / Medicinal chemistry
• Interest to acquire knowledge and apply innovative techniques to advance the medicinal chemistry project
• Handling of network cores in Linux, GPU systems, and scientific programming
Behavioral Skills:
• Ability to work in a multi-disciplinary team with excellent interpersonal skills
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