SNU Chemistry JRF Job Opening 2019- Application Details
Applications are invited for the post of Junior Research Fellow in a DST funded project entitled “Detoxification of Arsenic Compounds: Enzyme Mimetic Studies to Understand the Methylation of Arsenic by As(III) S-adenosylmethione (SAM) Methyltransferase (AS3MT)”, (SERB project number: CRG/2018/004591), under the supervision of Dr. Gouriprasanna Roy, Department of Chemistry, School of Natural Sciences (SNS), Shiv Nadar University (SNU), UP 201 314.
SNU Chemistry JRF Job. Applications are invited for the post of Junior Research Fellow in a DST funded project Department of Chemistry, School of Natural Sciences (SNS), Shiv Nadar University (SNU), UP. Interested and Eligible candidates may apply online. Check out all the details on the same below:
Position: Junior Research Fellow
Job Id: 163
No. of Positions: 1
Department: Chemistry
Job Type: Contract
Project Synopsis:
Arsenic (As) contamination is most prevalent in areas of West Bengal, Jharkhand, Bihar and Uttar Pradesh. Recent study reported that close to 150 million individuals consume drinking water from aquifers that are geologically contaminated with As at concentrations exceeding the upper limit of 0.010 mg L-1. Inorganic As (iAs) inhibits the activity of many vital antioxidant enzymes present in all tissues including thioredoxin (Trx), thioredoxin
reductase (TrxR) and glutathione peroxidase (GPx), glutathione reductase (GR) and decreases the intracellular glutathione (GSH) concentrations and, thereby it increases the production of reactive oxygen species (ROS) leading to DNA damage, protein oxidation, lipid peroxidation. Thus, development of a potential drug to counter the As-induced toxicity we need to have a clear understanding of the mechanism of As detoxification in human and in microbes.Objectives of this project:
Development of novel molecule(s) which can facilitate the methylation of arsenic (As) compounds, mainly As(III), to understand the methylation of As(III) by As(III) S-adenosylmethione (SAM) methyltransferase (AS3MT).
Design and synthesis of novel molecules which can efficiently covert inorganic and organic As to the biologically inert and less toxic species under physiologically relevant conditions.
Development of small molecules to facilitate the demethylation of organoarsenic compounds used in pesticides/herbicides and in animal husbandry (poultry and swine) to understand the cleavage of As-C bond by ArsI C-As lyase (completely opposite to objective 1).Cell-based and enzyme specific assays will be performed to evaluate the protective effect of novel compounds against the strong inhibition of important enzymes (like Trx, TrxR, GPx, and GR) caused by As.
Nature of work: Organic synthesis, complexation, enzyme kinetic studies, cell culture assays.
Essential & Desirable Qualification:
The candidate should have a Master’s degree (with a minimum of 55% marks or equivalent grade) in Chemistry from a UGC recognized University. The candidate should have good analytical skills. Familiarity with organic/inorganic synthesis will be preferred.
Candidates with CSIR/UGC-NET/JEST/GATE are encouraged to apply.
Fellowship: As per DST norms, fellowship is ₹31,000/- p.m. plus HRA as permissible for first two years. There will be enhanced fellowship in the third year as ₹35,000/- p.m. plus HRA.
Duration: 3 years
How To Apply:
Eligible and interested candidates should send their application with a complete CV (having personal details, academic qualifications, research experience, publications, name, affiliation and email address of two referees). Also, send photocopies of mark sheets/testimonials/ certificates, a recent passport size photograph, and other relevant documents as PDF attachment via email (preferable) or hard copies by Speed Post to the below address. All documents should reach the address on or before 15 September 2019.
Application deadline: 15 Sep 2019
