Schrödinger Job Vacancy – Chemistry Medicinal Chemistry Scientist
Dont forget to check out possible interview questions for this job below
Schrödinger is looking for a highly motivated medicinal chemist to join our team of scientists to advance drug discovery projects driven by cutting-edge computational methods in structure-based drug discovery. The ideal candidate will be an expert in modern methods of organic synthesis, hands-on experience in planning and execution of multi-step synthesis of complex heterocycles and/or natural products, analysis of structure-activity relationship (SAR) and multiparameter optimization for nominating drug candidates.
Job Title: Medicinal Chemistry Scientist
Location: Hyderabad
Eligbility Criteria, Skills and Experience:
- Ph.D. in Synthetic Organic Chemistry or Medicinal Chemistry with postdoctoral training (preferred) and 4+ years of relevant experience (Pharmaceutical/Biotech industry, CRO, or other relevant experience) with proven track record in medicinal chemistry.
- Expert knowledge of synthetic organic chemistry and strong track record of planning and hands-on execution of multi-step synthesis. Developing and directing clear synthetic routes/strategies towards complex molecules using state-of-the-art synthetic methodologies in a time-sensitive manner..
- Proficient in interpretation of analytical methods for compound characteristics (1D and 2D NMR, LC/MS, and other analytical techniques).
- Demonstrated track record of innovative solutions to research problems and delivering on project goals
- Excellent communication skills (verbal, written, and presentation)
Desired Skills and Experience:
- Experience in medicinal chemistry
- Experience with outsourcing synthetic chemistry via CRO’s
- Experience with structure-based drug design (SBDD) and actively collaborating with
- Computational Chemist / molecular modelers on drug discovery programs.
- Exposure to intellectual property management, patent analysis. Understanding of Biology, Pharmacology, DMPK, Toxicology and ability to integrate these disciplines toward successful project progression.
Responsibilities:
- Design and synthesis of the New Chemical Entities (NCEs) for drug discovery programs
Provide synthetic chemistry expertise and actively collaborate with computational chemists, medicinal chemists, biologists and other scientists in drug discovery projects - Design drug substances to address specific issues and optimize multi-parameter for identifying preclinical development candidates
- Design and optimize synthetic routes for small molecule targets emerging from next generation modeling approaches
- Manage CRO-based synthesis efforts to access small molecule targets
- Contribute to evaluation of new drug target opportunities.
- Work closely with the internal software development teams to improve Schrödinger’s drug discovery technologies.
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Important Interview Questions and Answers for the above job role:
- Can you describe your experience in medicinal chemistry and how it applies to this position?
Answer: Yes, I have a Ph.D. in Medicinal Chemistry and over 4 years of experience in the pharmaceutical industry. I have worked on drug discovery projects and have expertise in modern methods of organic synthesis, planning and execution of multi-step synthesis of complex heterocycles and natural products, analysis of structure-activity relationship (SAR), and multiparameter optimization for nominating drug candidates.
2. How do you approach designing and optimizing synthetic routes for small molecule targets emerging from next-generation modeling approaches?
Answer: I would start by analyzing the available data from computational modeling and assessing the feasibility of the proposed targets. Then, I would identify key structural features and design synthetic routes that are efficient and reliable. I would also consider scalability, cost, and sustainability in the design and optimization process.
3. What is your experience with outsourcing synthetic chemistry via CROs?
Answer: I have worked with CROs in the past and have experience in managing and monitoring their work to ensure high-quality results. I have also established clear communication channels and timelines to ensure that the projects stay on track.
4. How do you integrate different disciplines such as Biology, Pharmacology, and DMPK into your work?
Answer: I would collaborate closely with experts in those fields and incorporate their insights into the design and optimization process. For example, I would consider the pharmacological and toxicological profiles of the compounds in designing synthetic routes and optimizing multi-parameters for identifying preclinical development candidates.
5. Can you describe a project where you demonstrated innovative solutions to research problems and delivered on project goals?
Answer: One project where I demonstrated innovative solutions was the synthesis of a series of analogs of a lead compound. The lead compound had poor bioavailability, so we had to modify its structure to improve its pharmacological properties. I designed and synthesized several analogs with different structural features and assessed their pharmacological profiles. We identified a few promising candidates that showed improved pharmacological properties and were suitable for further development.
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