Syngene Research Investigator Job Opening – Chemistry & Pharma
Research Investigator.Syngene Investigator Job. Pharma Candidates with Phar & Chemistry degree are encouraged to apply online at Syngene for vacancies that are available. Syngene is hiring Pharmaceutical Science candidates. Interested and eligible candidates may apply online.
Job Description: Small Molecule Crystallography
Qualification – Master of Science (Chemistry/Materials science)/Master of Pharmacy (Analytical/Pharmaceutics) or equivalent degree with 5 plus years’ work experience as a Crystallographer OR PhD (Chemical Crystallography) with 0-4 years’ work experience
The candidate should be willing to work as an individual contributor as a Crystallographer (small molecule) with sound knowledge on crystallographic computational aspects and hands-on experience on other common solid-state characterisation techniques. Excellent interpersonal and presentation skills are necessary requirements.
Primary work responsibilities include but not limited to:
- Crystallography support for drug discovery and development projects
- Growing single crystals using various crystal growth techniques including multicomponent crystals (salt, cocrystal, etc.)
- Operation of single-crystal XRD instrument and associated accessories; sample preparation for non-ambient data collection (controlled atmosphere in the capillary, variable temperature, etc.)
- Complete data processing and structure solution and finalization including preparing a report with publishable data files as per international standards.
Performing basic and advanced powder diffraction analysis: data collection, phase purity analysis, profile fitting, powder pattern indexing, percentage crystallinity calculations, etc. - Performing complete crystal structure analysis e.g. molecular conformation, hydrogen bonding, void space analyses, etc.
- Performing lattice energy calculations for polymorphs; the understanding the structural landscape of a compound and predicting form relationships; polymorph prediction using basic tools.
- Understanding the structure-property (physiochemical) relationship among related compounds Carrying out crystal structure database; powder diffraction database; and basic literature searches
- Performing molecular and intermolecular geometry optimization and interaction energy (bond, motifs, etc) calculations
- Performing other solid-state characterization (DSC, TGA, IR, KF, DVS, etc.) to support various R&D activities.
- Experience and working knowledge in the area of polymorph screening of drug substance (desirable)
- Preparation and delivery of presentations in various internal and external forums Performing calibration and performance verification of instruments/equipment on a regular basis. Should have an understanding of basic troubleshooting and preventive maintenance of XRD instruments.
- Should be aware of/adhere to good documentation practices.
- Should be aware of/adhere to all the lab safety procedures.
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